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With poor plump incorporation, intestinal infections, severe protein power malnutrition, liver disease, or type V hyperparathyroidism (a genetic disorder)high-dose vitamin A and beta-carotene should be avoided in patients at high risk of lung cancer. Vitamin A may increase the risk of bleeding. Avoid use when taking agents that affect bleeding and clotting. Avoid in individuals with a known kindliness or allergy to vitamin A or any part of the formulation. Vitamin A should only be used within the optional dietary allowance, because vitamin A excess, as well as deficiency, has been associated with birth defects. Excessive doses of vitamin A have been associated with middle nervous system malformations. Vitamin A is excreted in human breast milk. The benefits or dangers to nursing infants are uncertain.Trevino that is functional to the skin is likely low risk for breastfeeding infants given its poor absorption; however, due to a lack of evidence, caution should be taken to prevent direct skin contact to the nursing infant and only water soluble cream or gel products should be applied.